The standard treatment for breast cancer has dramatically improved survival for women, but the fact remains that 40% of women still ultimately die from the disease. This underlines theneed for new and better treatments. Traditional cancer therapies are generally comprised of drugs and ionizing radiation, DNA damage and DNA machines. Such treatments preferably kill some types of cancer cells because these cells decreased ability to survive aDamage. However, normal cells, DNA damage suffered, but have the opportunity to repair their DNA. Unfortunately, the same genetic defect, the treatment may make cancer cells resistant to some, since it can also be less able to activate cell death in the face of DNA damage. The challenge of cancer treatment is now to exploit the properties of cancer cells that distinguish them from normal cells and at a later time and to specifically target cancer cells. Agrowing understanding of the biology of cancer cells leads to better treatment methods for the disease to direct destruction of cancer cells alone. have listed some of the latest and adventurous and treatment developed new strategies for the future diagnosis of breast cancer.
Six new strategies for the treatment of breast cancer
oncolytic viral therapy using 1 -. molecules that lack the tumor cells. Cancer cells in generalAbsence of p53 controls the cell cycle and cell replication. Viruses can attach to a host cell and replicate continuously within the cell. Then he broke when their numbers are sufficient to kill the cell and infect their neighbors. An adenovirus was then constructed that lacked the gene for the protein p53, the virus can then replicate only in cells in which p53 is inactivated cell cancer already, including many types. If this last Adenovirusinjected into a tumor, will replicate in and kill only tumor cells that lack p53, so that normal cells unharmed. This strategy is currently in clinical development.
2 -. Interventional Radiology scientists to investigate a technique that uses magnets to pull in tumors to chemotherapeutic agents. Microscopic particles are attached drugs for cancer and infused into the blood vessel that feeds the tumor. A rare earth magnetis located directly on the tumor. The magnet pulls the drug associated with particles from the blood vessel directly into the tumor. This technique is still experimental, but early research is promising. The scientists hope that it enhances the effects of chemotherapy drugs and avoid side effects.
3 -. gene therapy involves the change in the patient's genetic material to fight or prevent cancer. Although the science of gene therapy is stillphases of the trial, the researchers hope that can be synthesized for use in future therapy as follows:
Age of cells in the patient's natural immune system is fighting cancer with genes that allow cancer cells to attack more;
Genetically modified cells so the cancer patient's immune system is to defend the modified tumor cells and thereby contribute to the vaccine as a cancer;
Replacing genes required for cancer growth with"Good" genes and inject a tumor with genes that the agent is more vulnerable to cancer-fighting.
Make normal tissue resistance to chemotherapy, so that drugs destroy tumors without damaging healthy tissue.
. 4 breast cancer vaccines - vaccination strategies, the patient's own immune system to intervene to eliminate the cells of this cancer sustainable one. The advantage of this is of low toxicity and high specificity and Antibody effect on the cellular memory.
. 5 genes used by breast cancer resistance - to Dana Faber Cancer Institute have found a gene that chemotherapy drugs, which may provide researchers with a high risk of recurrence of the treated disease were some in the choice of breast cancer. The discovery may choose to help the doctor use the anti-tumor and to eliminate false ineffective.
6th more detailed within> Diagnosis of cancer - breast cancer can now be characterized at the molecular level to obtain expression profiles of thousands of genes up. These profiles can be grouped into subclasses breast cancers that are common features and the prognosis and likely response to particular treatments. More targeted cancer treatments can then be made for each subclass
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